Clonidine (Catapres)

Clonidine (Catapres)


Clonidine Hydrochloride is an antihypertensive drug with the central action to treat hypertension (high blood pressure). As a central alpha-agonist, Clonidine reduces the blood pressure by dilating blood vessels and slowing heart rate.

The drug is supplied as tablets of Clonidine Hydrochloride 0.1 mg, Clonidine Hydrochloride 0.2 mg, and Clonidine Hydrochloride 0.3 mg.

Indications for Clonidine use


  • Hypertension (both as a monotherapy and in combination with other drugs).

Contraindications to Clonidine:


  • Hypersensitivity to the drug;
  • Pregnancy (no reported data on the drug efficacy).
Extra care is recommended in:
  • heart disease (including coronary heart disease);
  • irregular heart rhythm;
  • heart attack or stroke in history;
  • kidney disease.

Side effects of Clonidine:


  • constipation
  • dizziness, drowsiness, insomnia, headache
  • dry mouth, nausea.
Immediate medical assistance is required in:
  • severe allergic reactions (rash, itching, difficulty breathing, chest tightness, swelling of the tongue, face, lips);
  • blurred vision or other vision disorders;
  • chest pain;
  • fainting;
  • rapid, slow or chaotic heartbeat
  • unusual mental state (depression, hallucination, agitation);
  • acute or long headache or dizziness
  • swelling of the hands, knees or feet.
Clonidine is a fast-acting drug lowering the blood pressure within 30-60 minutes after oral intake. The maximum effect is observed in 2-4 hours.

The sudden drug cessation without a doctor's recommendation may cause irritability, agitation, tremor following by high blood pressure and plasma catecholamine concentration. A risk of these reactions is higher if the drug was taken in high doses and in combined therapy with beta blockers.

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