Hydrochlorothiazide (Microzide)

Hydrochlorothiazide (Microzide)

Hydrochlorothiazide is a thiazide diuretic. Its main effect is lowering blood pressure. The drug is supplied as coated tablets, in 10 pill blister pack or in 3-5 blister boxes.

Indications for use Hydrochlorothiazide

Indications for Hydrochlorothiazide use: hypertension, nephrotic syndrome, edema syndrome, renal failure, chronic heart failure, fluid retention in obesity.
Also the drug is effective in subcompensated glaucoma forms and diabetes insipidus.

Hydrochlorothiazide is not recommended to patients with severe kidneys disorders, gout, liver failure, diabetes mellitus complications and to people with hypersensitivity to sulfonamides.

Extra caution should be taken in patients with mild gout and diabetes mellitus. In renal failure Hydrochlorothiazide should be used under electrolyte level control. Long-term use is recommended only with potassium. The drug gets into breast milk, so do not use it during breast-feeding.

Side effects of Hydrochlorothiazide

Possible side effects of Hydrochlorothiazide include: nausea, weakness, orthostatic hypotension, hyperglycemia, hypomagnesemia, hypercalcemia, hypokalemia, alkalosis, hyponatremia, hyperuricemia, tachycardia, fatigue, vomiting, diarrhea, dizziness, and paresthesia.

Rare side effects include: pancreatitis, thrombocytopenia, neutropenia, blurred vision, allergic dermatitis.

Hydrochlorothiazide action is based on fast excretion of potassium, bicarbonate and magnesium. In addition, it impairs the reabsorption of ions of chloride and sodium in distal tubule of the nephron.
The diuretic effect is achieved in two hours and lasts for 12 hours. The drug reduces polyuria in people with diabetes insipidus, and lower intraocular pressure in patients with glaucoma.

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