Mirapex (Pramipexole)

Mirapex (Pramipexole)


Mirapex (Pramipexole) is antiparkinsonian agent, dopamine drug (a selective dopamine receptor agonist). Pramipexole selectively stimulates dopamine receptors in the brain, including the basal ganglia and cortex of the brain regulating muscle tone.

Pramipexole inhibits dopamine synthesis, release and exchange, protecting dopamine neurons against progressive degeneration in response to the ischemia and methamphetamine neurotoxicity.

Pharmaceutical Mirapex form: Pramipexole 1mg, Pramipexole 1.5mg and Pramipexole 2.5mg.

Indications for use Mirapex


Mirapex is used for long-term treatment of Parkinson's disease as monotherapy or in combination with levodopa.

Contraindications to Mirapex use:


Contraindications to Mirapex are allergic to Pramipexole or other drug components. In renal insufficiency and hypotension, Mirapex is indicated in lower dose. The drug effect on pregnancy and breast-feeding has not been investigated yet.

Considering Pramipexole excretion properties, patients with hepatic impairment are not required to reduce a dose. Driving is not recommended during the drug treatment.

Side effects of Mirapex


The most common adverse effect while taking Mirapex in the early disease stages is drowsiness and constipation, and later dyskinesis and hallucination, especially combined with levodopa therapy. These side effects disappear soon.

In rare cases mental confusion, muscle rigidity, akathisia, delirium, extrapyramidal syndrome, asthenia, amnesia, myoclonus, and suicidal thoughts are observed.
Dysphagia, flatulence, and vomiting can be observed in the digestive system.
Paralysis of accommodation, high intraocular pressure and amblyacousia are sometimes experienced as well.

Numerous clinical trials have proved the high efficacy of Mirapex in early and late phases of Parkinson's disease. Clinical improvement is achieved in most of patients.

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