Spiriva (Tiotropium)

Spiriva (Tiotropium)

Spiriva is a drug of M-cholinoblocker, containing an active component tiotropium bromide. It is used as bronchodilator, blocks M-cholinergic receptors of the smooth muscles of the tracheobronchial tree. It is characterized by similarity to different subtypes of M1 to M5muscarinic receptors. M3 receptors inhibition in the respiratory tracts relaxes the smooth muscles. Tiotropium administered in inhalation route provides a selective effect, with no systemic anticholinergic side effects.

Spiriva is supplied as capsules with inhalation powder Boehringer-Ingelheim by 18mcg.

Indications for Spiriva use

Indications for Spiriva use chronic obstructive pulmonary disease (including chronic bronchitis and emphysema).

Contraindications to Spiriva

• hypersensitivity
• pregnancy,
• age under 18 years,
• angle-closure glaucoma,
• prostatic hyperplasia,
• bladder neck obstruction.

Side effects of Spiriva

Spiriva may cause the following side effects: dry mouth (usually disappears soon), constipation, coughing, oropharynx irritation, paradoxical bronchospasm, tachycardia, difficult urination, urinary retention (in men with risk factors), angioneurotic edema, blurred vision , high intraocular pressure. In case of any side effects, the symptomatic treatment is indicated.

Spiriva is inhaled with a special device, 1 capsule a day at the same time. Patients should be trained how to use inhaler. The drug should not be used for relief of acute bronchospasm as inhalation drug may lead to bronchospasm.

High similarity to receptors and slow dissociation provide a stable and long bronchodilator effect in patients with COPD. Spiriva significantly improves the lung function in 30 minutes after a single dose, increases morning and evening peak expiratory flow rate. Pharmacodynamics is reached within 1 week, and bronchodilator effect is observed on the 3 day, depending on a dose and lasts for at least 24 hours, so the drug should not be taken more than once a day.

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